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Home Breaking News

Why some people find it harder to lose weight, according to science

January 5, 2026
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Why some people find it harder to lose weight, according to science
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Living Well

The beginning of a brand new yr is a time when custom dictates we set targets for the months forward.

For a lot of, this will imply desirous about more healthy diets and shedding the kilos, particularly after indulging through the festive interval.

However whereas consuming properly and shifting extra is a good place to begin, weight reduction isn’t essentially all about willpower and self-control. Scientists have confirmed that some discover it simpler than others to drop the kilos, and it’s all all the way down to your genetics.

Dr Giles Yeo, professor of molecular neuroendocrinology on the College of Cambridge and creator of Gene Consuming, spoke to The Unbiased about how your genetic make-up can affect your perspective in direction of meals, and due to this fact your weight.

Studies show genetics play a major role in weight loss, according to experts

open picture in gallery

Research present genetics play a significant function in weight reduction, in line with consultants (Getty/iStock)

“Merely put, some persons are pushed to meals for a myriad of various causes,” he stated. “Therefore they discover it tougher to say no, they eat extra, and so they’re going to be bigger than another person.

“So for a similar motive, some individuals discover it tougher to shed weight.”

Dr Yeo stated there are “over 1,000 genes” which might be concerned in our feeding behaviour, and that these have a transparent affect on our physique weight. Some of the researched is the melanocortin 4 receptor (MC4R) – a key mind receptor that helps regulate urge for food, physique weight, and vitality stability.

In 1998, scientists first found that genetic mutations on this receptor are linked to weight problems as early as childhood. Dr Yeo stated as we speak, it’s identified that about 0.3 per cent of the overall inhabitants has certainly one of quite a lot of mutations on this gene. When extrapolated to the UK inhabitants, that is greater than 200,000 individuals.

“Greater than 200,000 individuals inside this nation will doubtlessly have a damaged fats sensor,” he stated. “What meaning is that they assume they’ve much less fats once they really do.”

Dr Yeo defined how the mutation can have an enormous and confirmed affect on individuals’s physique weight. “When individuals with this mutation attain 18 years outdated, they’re on common practically 18kg heavier than these with out,” he stated. “That’s 5 BMI factors.”

Considerably, out of the inhabitants who wrestle with well being points associated to “extreme weight problems” and are handled in a clinic, the share with an MC4R mutation jumps to something from 2 per cent to 10 per cent, he stated.

Obesity rates are rising in the UK

open picture in gallery

Weight problems charges are rising within the UK (AFP by way of Getty Pictures)

“So in the event you go to the inhabitants with extreme weight problems, the variety of individuals with the mutation actually jumps,” he added.

Starvation cues are one other issue that may affect how straightforward individuals discover it to shed weight, in line with Dr Yeo. He informed The Unbiased broadly the mind wants two items of knowledge to affect your starvation cues – how a lot fats you will have, and what you’re at present consuming and have simply eaten.

It will get these by sensing hormones out of your intestine and intestines – however individuals’s brains sense these in another way, therefore why some individuals really feel starvation cues in another way from others.

However Dr Yeo identified that genetics doesn’t inform the entire story. In accordance with the Well being Basis’s 2025 report, round 60 per cent of UK adults are obese, with this quantity rising steadily over the past decade.

He stated each our meals surroundings – primarily the selection of meals accessible to us and the accessibility of processed meals – and our constructed surroundings, such because the prevalence of office-based jobs, are additionally main contributors to why some individuals wrestle to shed weight.

Dr Yeo believes we need to ‘fix our food environment’

open picture in gallery

Dr Yeo believes we have to ‘repair our meals surroundings’ (PA Archive)

“That has pushed the prevalence of weight problems, however not everybody has weight problems,” he stated. “Genetics explains why some individuals discover it troublesome to say no to this energy-rich surroundings that we have now.”

Narratives of self-control and willpower can due to this fact be “unhelpful” in conversations about methods to assist society as an entire turn into more healthy, in line with Dr Yeo.

As an alternative, he believes we have to “repair the meals surroundings” – one thing he stated a brand new authorities ban on junk meals promoting on-line always and on tv earlier than 9pm may also help with.

However Dr Yeo acknowledged radical transformations to our grocery store choices are usually not one thing people have the facility to decide on. As an alternative, he inspired individuals to deal with the meals surroundings they’ll management – their very own properties.

“In case you’re making an attempt to shed weight, it’s worthwhile to be trustworthy with your self about why you’re consuming,” he stated. “Some individuals eat as a result of they’re hungry, different individuals eat as a result of they’re pressured.

“Then it’s worthwhile to know what you wish to eat. What’s your weak point? In case you perceive what you wish to eat underneath these circumstances, you may try to cut back these specific meals inside your family.”



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