AsianScientist (Feb. 20, 2026) –Individuals who climb to excessive altitudes usually expertise complications, a major symptom of acute mountain illness (AMS). Whereas AMS and its related complications are thought to consequence from hypoxia, i.e., lowered oxygen supply to physique tissues, the underlying mechanisms, notably the position of regional cerebral blood circulation, should not properly understood.
Earlier research on AMS have been carried out, however few have lasted lengthy sufficient or taken place in actual high-altitude environments.
To handle this hole, a crew from the Osaka Metropolitan College Analysis Centre for City Well being and Sports activities measured blood circulation and vessel diameter within the inner carotid and vertebral arteries of eight wholesome males on the summit of Mount Fuji, 3,776 metres above sea stage.
The research was carried out over three days, throughout which the crew concurrently recorded signs of altitude illness, together with complications and fatigue. The outcomes have been printed within the Journal of Utilized Physiology.
Eight wholesome males aged 22 to 46 years have been recruited for the research. All members have been non-smokers and free from cardiovascular, metabolic, or neurological illness, in addition to migraines and substance dependence. The members have been bodily energetic however not engaged in formal coaching programmes and had not been at altitudes above 1,500 metres within the earlier six months. Ultrasound screening confirmed the absence of vascular abnormalities.
Contributors have been instructed to keep away from alcohol and strenuous bodily exercise for at the very least 24 hours earlier than testing and to chorus from consuming caffeine for 12 hours beforehand. They have been inspired to drink greater than two litres of fluid every day, though hydration and sleep weren’t formally monitored.
The research was carried out on the summit of Mount Fuji, a well-liked climbing vacation spot that draws greater than 250,000 guests every summer time. Consequently, AMS is a big concern. Measurements have been taken at low altitude (450 m) and on three consecutive days on the summit.
On the day of ascent, members travelled by car to a base camp at 1,280 meters, then reached the summit inside three hours by bulldozer, arriving round 9:00 a.m. All measurements have been carried out between 1:30 p.m. and 5:30 p.m., at the very least two hours after a light-weight meal, to minimise the results of digestion on cerebral blood circulation.
Throughout every session, members rested in a supine place for half-hour earlier than information assortment started, which lasted 20 minutes in the identical place. They have been requested to breathe usually and stay silent. Signs of AMS have been recorded earlier than every measurement. After spending three nights on the summit, members descended on foot and returned to low altitude.
Ambient stress, temperature, and humidity have been monitored at every web site all through the research.
Outcomes confirmed that blood circulation and vessel diameter within the inner carotid artery elevated with longer high-altitude publicity, whereas vertebral artery circulation rose on the primary day after which declined. Headache severity elevated at altitude and was intently linked to adjustments in carotid artery diameter and vertebral artery circulation and velocity.
Though total AMS signs additionally elevated, they have been largely unrelated to blood circulation measures, apart from vertebral artery velocity. The findings counsel that elevated regional cerebral blood circulation, notably within the carotid and vertebral arteries, might drive high-altitude complications and contribute to AMS.
“These findings make clear one mechanism behind altitude illness onset and might probably assist in managing climbers’ bodily situations throughout mountain hikes and high-altitude coaching,” stated Kazunobu Okazaki, director, Analysis Centre for City Well being and Sports activities, Osaka Metropolitan College.
“We imagine that additional investigation into particular person variations, gender variations, and the acclimatization course of throughout long-term stays will yield insights relevant to the prevention and early administration of altitude illness. As well as, the connection between cerebral blood circulation and complications can also contribute to understanding different headache issues, corresponding to migraines,” he added.
Supply: Osaka Metropolitan College ; Picture: Tomasvi/Freepik
The research might be discovered at Impact of short-term high-altitude acclimatization on the connection between cerebral blood circulation and signs of delicate acute mountain illness in males
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